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sisunatovir (rv521)  (Pfizer Inc)

 
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    Pfizer Inc sisunatovir (rv521)
    The research and development progress of RSV therapeutic agents.
    Sisunatovir (Rv521), supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sisunatovir (rv521)/product/Pfizer Inc
    Average 90 stars, based on 1 article reviews
    sisunatovir (rv521) - by Bioz Stars, 2026-02
    90/100 stars

    Images

    1) Product Images from "Vaccine and therapeutic agents against the respiratory syncytial virus: resolved and unresolved issue"

    Article Title: Vaccine and therapeutic agents against the respiratory syncytial virus: resolved and unresolved issue

    Journal: MedComm

    doi: 10.1002/mco2.70016

    The research and development progress of RSV therapeutic agents.
    Figure Legend Snippet: The research and development progress of RSV therapeutic agents.

    Techniques Used:



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    Image Search Results


    Antiviral Activity of Anti-RSV Compounds Against Identified Variants

    Journal: The Journal of Infectious Diseases

    Article Title: EDP-938 Has a High Barrier to Resistance in Healthy Adults Experimentally Infected with Respiratory Syncytial Virus

    doi: 10.1093/infdis/jiae471

    Figure Lengend Snippet: Antiviral Activity of Anti-RSV Compounds Against Identified Variants

    Article Snippet: AK0529 (Ziresovir) and RV521 (Sisunatovir) were purchased from MedChemExpress.

    Techniques: Activity Assay

    N:L139I mediates resistance to EDP-938. HEp-2 cells were infected with the indicated recombinant strain of RSV-A expressing an mKATE reporter at a multiplicity of infection of 0.1. At the time of infection, cells were treated with the indicated concentration of the listed compound or DMSO vehicle control: ( A ) EDP-938, ( B ) EDP-323, ( C ) AK0529, and ( D ) RV521. Five days postinfection, the mKATE fluorescence intensity was measured. Percent viral inhibition at each concentration was calculated. Data are expressed as the mean percent viral inhibition at each concentration ± standard deviation from at least 3 independent biological replicates. Dotted lines indicate 50% and 90% viral inhibition. Abbreviations: DMSO, dimethyl sulfoxide; N, nucleoprotein; RSV, respiratory syncytial virus; WT, wild type.

    Journal: The Journal of Infectious Diseases

    Article Title: EDP-938 Has a High Barrier to Resistance in Healthy Adults Experimentally Infected with Respiratory Syncytial Virus

    doi: 10.1093/infdis/jiae471

    Figure Lengend Snippet: N:L139I mediates resistance to EDP-938. HEp-2 cells were infected with the indicated recombinant strain of RSV-A expressing an mKATE reporter at a multiplicity of infection of 0.1. At the time of infection, cells were treated with the indicated concentration of the listed compound or DMSO vehicle control: ( A ) EDP-938, ( B ) EDP-323, ( C ) AK0529, and ( D ) RV521. Five days postinfection, the mKATE fluorescence intensity was measured. Percent viral inhibition at each concentration was calculated. Data are expressed as the mean percent viral inhibition at each concentration ± standard deviation from at least 3 independent biological replicates. Dotted lines indicate 50% and 90% viral inhibition. Abbreviations: DMSO, dimethyl sulfoxide; N, nucleoprotein; RSV, respiratory syncytial virus; WT, wild type.

    Article Snippet: AK0529 (Ziresovir) and RV521 (Sisunatovir) were purchased from MedChemExpress.

    Techniques: Infection, Recombinant, Expressing, Concentration Assay, Control, Fluorescence, Inhibition, Standard Deviation, Virus

    The research and development progress of RSV therapeutic agents.

    Journal: MedComm

    Article Title: Vaccine and therapeutic agents against the respiratory syncytial virus: resolved and unresolved issue

    doi: 10.1002/mco2.70016

    Figure Lengend Snippet: The research and development progress of RSV therapeutic agents.

    Article Snippet: , Sisunatovir (RV521) , SM , Pfizer (Reviral previously) , Phase 2.

    Techniques:

    Structures ofGS-5806 ( 9 ), JNJ-53718678 ( 10 ), BMS-433771 ( 11 ), TMC-353121 ( 12 ), RV521 ( 13 ), 3,4-DCQAME ( 14 ) and Quercetin pentaacetate ( 15 ).

    Journal: Molecules

    Article Title: Prevention and Potential Treatment Strategies for Respiratory Syncytial Virus

    doi: 10.3390/molecules29030598

    Figure Lengend Snippet: Structures ofGS-5806 ( 9 ), JNJ-53718678 ( 10 ), BMS-433771 ( 11 ), TMC-353121 ( 12 ), RV521 ( 13 ), 3,4-DCQAME ( 14 ) and Quercetin pentaacetate ( 15 ).

    Article Snippet: ReViral in the UK has developed a drug, a fusion inhibitor called RV521 ( 13 ) , that inhibits the virus fusion phase of the virus by targeting the RSV F protein (EC 50 = 1 nM) [ ].

    Techniques: